![](/assets/images/picto-drapeau-france-3a76576a5d60a512053b4612ab58dae5.png)
6. Sensitization. Allergy
Sensitization occurs following repeated contact, even at low doses, and after a more or less long latency period. It is triggered by further contact with the substance, even at very low concentration.
6.1 Two main forms of awareness-raising
Type IV contact allergy manifests as contact eczema and dermatitis, mediated by T lymphocytes derived from the thymus. The effect is characterized by irritation (redness) and intracellular edema of varying intensity at the site of contact of the substance with the skin.
Type I humoral allergy manifests as rhinitis, sneezing, asthma or angioedema, and pulmonary edema in its severe form. The immune mediators are IgM and IgG immunoglobulins, secreted into circulating blood by B lymphocytes located...
Exclusive to subscribers. 97% yet to be discovered!
You do not have access to this resource.
Click here to request your free trial access!
Already subscribed? Log in!
![](/assets/images/logo-eti-286623ed91fa802ce039246e516e5852.png)
The Ultimate Scientific and Technical Reference
This article is included in
Safety and risk management
This offer includes:
Knowledge Base
Updated and enriched with articles validated by our scientific committees
Services
A set of exclusive tools to complement the resources
Practical Path
Operational and didactic, to guarantee the acquisition of transversal skills
Doc & Quiz
Interactive articles with quizzes, for constructive reading
Sensitization. Allergy
Bibliography
Websites
Anses – Nanomaterials
Anses – Endocrine disruptors
CEA – Nanosafe
ECHA – Nanomaterials
...Regulations
Regulation (EC) No 1272/2008 of the European Parliament and of the Council of December 16, 2008 on classification, labeling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (see various amendments).
Arrêté du 7 décembre 2009 (JO du 16 décembre 2009, 3 pages): modification des arrêtés du 20 avril 1994 et...
Directory
ATC – Association de toxicochimie
ARET – Association for Research in Toxicology
Exclusive to subscribers. 97% yet to be discovered!
You do not have access to this resource.
Click here to request your free trial access!
Already subscribed? Log in!
![](/assets/images/logo-eti-286623ed91fa802ce039246e516e5852.png)
The Ultimate Scientific and Technical Reference