6. Sensitization. Allergy
Sensitization occurs following repeated contact, even at low doses, and after a more or less long latency period. It is triggered by further contact with the substance, even at very low concentration.
6.1 Two main forms of awareness-raising
Type IV contact allergy manifests as contact eczema and dermatitis, mediated by T lymphocytes derived from the thymus. The effect is characterized by irritation (redness) and intracellular edema of varying intensity at the site of contact of the substance with the skin.
Type I humoral allergy manifests as rhinitis, sneezing, asthma or angioedema, and pulmonary edema in its severe form. The immune mediators are IgM and IgG immunoglobulins, secreted into circulating blood by B lymphocytes located...
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Sensitization. Allergy
Phototoxicity. Photo-irritation. Photo-allergy
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...Regulations
Regulation (EC) No 1272/2008 of the European Parliament and of the Council of December 16, 2008 on classification, labeling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (see various amendments).
Arrêté du 7 décembre 2009 (JO du 16 décembre 2009, 3 pages): modification des arrêtés du 20 avril 1994 et...
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