Français
10. Genotoxicity. Mutagenesis
Strictly speaking, a "mutation" is any sudden, permanent change in the genetic make-up, involving a change in the number or quality of genes (DNA alterations, DNA adducts, chromosome breaks).
We distinguish :
mutagenesis: hereditary mutations in germ cells (reproductive cells) theoretically transmissible to offspring;
genotoxicity: alteration of the cell's genetic heritage that cannot be passed on to offspring, resulting in cellular dysfunction that can lead to cancer of the organs affected.
Toxins act on chromosomes and genetic material (DNA).
10.1 Actions on chromosomes (chromosomal aberrations)
...
The Ultimate Scientific and Technical Reference
This article is included in
Safety and risk management
This offer includes:
Knowledge Base
Updated and enriched with articles validated by our scientific committees
Services
A set of exclusive tools to complement the resources
Practical Path
Operational and didactic, to guarantee the acquisition of transversal skills
Doc & Quiz
Interactive articles with quizzes, for constructive reading
Genotoxicity. Mutagenesis
Carcinogenesis
Bibliography
Websites
Anses – Nanomaterials
Anses – Endocrine disruptors
CEA – Nanosafe
ECHA – Nanomaterials
...Regulations
Regulation (EC) No 1272/2008 of the European Parliament and of the Council of December 16, 2008 on classification, labeling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (see various amendments).
Arrêté du 7 décembre 2009 (JO du 16 décembre 2009, 3 pages): modification des arrêtés du 20 avril 1994 et...
Directory
ATC – Association de toxicochimie
ARET – Association for Research in Toxicology
The Ultimate Scientific and Technical Reference
