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5. Local tolerance
5.1 Respiratory tract
These are the first routes of contact and entry of toxic substances into the body.
Local clinical signs are as follows.
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Nasal :
nasal irritation (acids, acrylates, etc.),
degeneration of the olfactory epithelium (formaldehyde, acids);
Note also sensory irritation = neurological inflammation perceived in the nose, by excitation of the fifth cranial nerve, but which does not give rise to clinical signs of irritation.
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Pulmonary :
alteration, paralysis or depletion of the cilia of the epithelial cells of the tracheobronchial...
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Local tolerance
Sensitization. Allergy
Bibliography
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Anses – Nanomaterials
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...Regulations
Regulation (EC) No 1272/2008 of the European Parliament and of the Council of December 16, 2008 on classification, labeling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (see various amendments).
Arrêté du 7 décembre 2009 (JO du 16 décembre 2009, 3 pages): modification des arrêtés du 20 avril 1994 et...
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