5. Local tolerance
5.1 Respiratory tract
These are the first routes of contact and entry of toxic substances into the body.
Local clinical signs are as follows.
-
Nasal :
nasal irritation (acids, acrylates, etc.),
degeneration of the olfactory epithelium (formaldehyde, acids);
Note also sensory irritation = neurological inflammation perceived in the nose, by excitation of the fifth cranial nerve, but which does not give rise to clinical signs of irritation.
-
Pulmonary :
alteration, paralysis or depletion of the cilia of the epithelial cells of the tracheobronchial...
The Ultimate Scientific and Technical Reference
This article is included in
Safety and risk management
This offer includes:
Knowledge Base
Updated and enriched with articles validated by our scientific committees
Services
A set of exclusive tools to complement the resources
Practical Path
Operational and didactic, to guarantee the acquisition of transversal skills
Doc & Quiz
Interactive articles with quizzes, for constructive reading
Local tolerance
Sensitization. Allergy
Bibliography
Websites
Anses – Nanomaterials
Anses – Endocrine disruptors
CEA – Nanosafe
ECHA – Nanomaterials
...Regulations
Regulation (EC) No 1272/2008 of the European Parliament and of the Council of December 16, 2008 on classification, labeling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (see various amendments).
Arrêté du 7 décembre 2009 (JO du 16 décembre 2009, 3 pages): modification des arrêtés du 20 avril 1994 et...
Directory
ATC – Association de toxicochimie
ARET – Association for Research in Toxicology
The Ultimate Scientific and Technical Reference
