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4. Expression of toxic hazard
DANGER = static notion of potentiality
Intrinsic property of a chemical substance, set of physical and toxicological characteristics presenting a potential hazard.
RISK = dynamic notion of contingency
All the circumstances that allow the expression of a potential danger.
For some substances identified as endocrine disruptors and/or genotoxic, the dose/intensity relationship is not directly applicable. A single exposure to a low dose may be enough to trigger deleterious biological effects.
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Expression of toxic hazard
Local tolerance
Bibliography
Websites
Anses – Nanomaterials
Anses – Endocrine disruptors
CEA – Nanosafe
ECHA – Nanomaterials
...Regulations
Regulation (EC) No 1272/2008 of the European Parliament and of the Council of December 16, 2008 on classification, labeling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (see various amendments).
Arrêté du 7 décembre 2009 (JO du 16 décembre 2009, 3 pages): modification des arrêtés du 20 avril 1994 et...
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ARET – Association for Research in Toxicology
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