12. Conclusion
While studies on laboratory animals are still widely used, they are increasingly being replaced by studies on cells or tissues (in vitro), as well as by computer simulations such as the Quantitative Structure Activity Relationship (QSAR) and Artificial Intelligence computer simulations or modeling.
The study of the hazards of all chemical substances is continued in the REACH dossier, which obliges manufacturers to complete toxicological and ecotoxicological data according to the tonnage of substances produced in Europe. This results in the definition of exposure limits for workers and consumers (DNEL and DMEL), which enable more effective control of the risks associated with exposure to chemical substances.
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Bibliography
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Anses – Nanomaterials
Anses – Endocrine disruptors
CEA – Nanosafe
ECHA – Nanomaterials
...Regulations
Regulation (EC) No 1272/2008 of the European Parliament and of the Council of December 16, 2008 on classification, labeling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (see various amendments).
Arrêté du 7 décembre 2009 (JO du 16 décembre 2009, 3 pages): modification des arrêtés du 20 avril 1994 et...
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