3. Bioavailability in the body
Bioavailability is the ability of a substance to cross physiological barriers, enter the bloodstream, distribute itself throughout the body and come into contact with organs. It is used to define the internal dose of a chemical substance.
3.1 Distribution
After entering the body, the chemical is rapidly distributed to the organs. In general, the initial phase takes place in the bloodstream, while distribution to the organs is largely determined by the chemical's affinity for them.
Passage through cell membranes is either by :
passive diffusion through aqueous conduits or pores for small water-soluble molecules and ions and possibly nanomaterials;...
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Bioavailability in the body
Expression of toxic hazard
Bibliography
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Anses – Nanomaterials
Anses – Endocrine disruptors
CEA – Nanosafe
ECHA – Nanomaterials
...Regulations
Regulation (EC) No 1272/2008 of the European Parliament and of the Council of December 16, 2008 on classification, labeling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (see various amendments).
Arrêté du 7 décembre 2009 (JO du 16 décembre 2009, 3 pages): modification des arrêtés du 20 avril 1994 et...
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