1. General

1.1 Selection and sizing principles

The type of bioreactor to be used depends on the number of phases involved in the bioreaction: a single liquid phase, or a gas phase dispersed in a liquid phase (in the case of aerobic cultures), or a solid phase dispersed in a liquid phase (in the case of immobilized enzymes, for example).

It should be noted that, as micro-organisms are smaller than 20 µm in size and have a density very close to that of the culture media, suspensions of micro-organisms in culture media are considered to be a pseudo-homogeneous liquid phase. Of course, this assumption is no longer valid if the micro-organisms tend to agglomerate to form flocs (yeast) or pellets (filamentous fungi).

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General

(1) - VAN'T RIET (K.) - Mass Transfer in Fermentation. - Trends in biotechnology 1, 4, 113, 1983.
(2) - AKITA (K.), YOSHIDA (F.) - Gas Holdup and Volumetric Mass Transfer in Bubble Columns. - Ind. Eng. Chem. Des. Dev....

- http://www.sudoc.abes.fr
MASSÉ (A.) - Contribution à la mise en place d'un réacteur enzymatique à membrane travaillant en milieu supercritique. - Université des sciences et techniques du Languedoc (2001)...