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8. Systemic toxicity
8.1 Definitions
There are two forms of systemic toxicity:
acute toxicity, the effects of which occur after a single, strong exposure over a short period (a few hours);
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long-term toxicity (in two forms):
subacute, the effects of which develop progressively with moderate but repeated exposure over a period of days to weeks,
chronic, whose effects develop over the long term following low but repeated exposure over a long exposure period lasting months or years.
Toxicology studies are generally based on a dose/duration relationship. Toxic doses are very high in acute studies, and much lower...
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...Regulations
Regulation (EC) No 1272/2008 of the European Parliament and of the Council of December 16, 2008 on classification, labeling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (see various amendments).
Arrêté du 7 décembre 2009 (JO du 16 décembre 2009, 3 pages): modification des arrêtés du 20 avril 1994 et...
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