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10. Genotoxicity. Mutagenesis
Strictly speaking, a "mutation" is any sudden, permanent change in the genetic make-up, involving a change in the number or quality of genes (DNA alterations, DNA adducts, chromosome breaks).
We distinguish :
mutagenesis: hereditary mutations in germ cells (reproductive cells) theoretically transmissible to offspring;
genotoxicity: alteration of the cell's genetic heritage that cannot be passed on to offspring, resulting in cellular dysfunction that can lead to cancer of the organs affected.
Toxins act on chromosomes and genetic material (DNA).
10.1 Actions on chromosomes (chromosomal aberrations)
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Genotoxicity. Mutagenesis
Carcinogenesis
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...Regulations
Regulation (EC) No 1272/2008 of the European Parliament and of the Council of December 16, 2008 on classification, labeling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (see various amendments).
Arrêté du 7 décembre 2009 (JO du 16 décembre 2009, 3 pages): modification des arrêtés du 20 avril 1994 et...
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