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6. Catalytic Appel reaction
6.1 Introduction to Call Reaction
Another nucleophilic substitution reaction promoted by phosphines is the Appel reaction . In this transformation, alcohols (R 3 C-OH) are converted to alkyl halides (R 3 C-X), using a stoichiometric amount of triphenylphosphine. This reaction is commonly used in academic research and in industry since it allows the rapid creation of C-X bonds that are very useful for obtaining more molecular diversity....
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Catalytic Appel reaction
Phosphine and asymmetric catalytic processes
Bibliography
Standards and norms
- Environmental management – Lifecycle analysis – Requirements and guidelines - NF EN ISO 14044 - (2006)
- Lifecycle analysis – Principles and framework - NF EN ISO 14040 - (2006)
Patents
O'BRIEN (C.J.) (University of Texas, USA), Catalytic Wittig and Mitsunobu reactions. US Patent 8901365, (2014).
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