Article | REF: IN405 V1

Phosphine redox catalysis

Authors: Charlotte LORTON, Arnaud VOITURiEZ

Publication date: March 10, 2021

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5. Catalytic Mitsunobu reaction

5.1 Introduction to the Mitsunobu reaction

Among the other major reactions promoted by phosphines and commonly used in laboratories worldwide is the Mitsunobu reaction, discovered in 1967 by O. Mitsunobu (figure 17 ) . This transformation involves the conversion of primary or secondary alcohols into esters, amines, thioethers and many other organic compounds, and has been used on numerous occasions as a key step in the synthesis...

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Catalytic Mitsunobu reaction