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6. Conclusion
Industrial processes for culturing animal cells to produce therapeutic molecules are currently booming, particularly in the recombinant antibody and vaccine sectors. In addition to a strict regulatory framework, these processes are characterized by specific features such as nutritional requirements imposing a complex formulation of culture media, high cell sensitivity to their physico-chemical environment (pH, temperature, stress, etc.), and delicate operation. As a result, there is still considerable scope for improving their performance, notably through research into new cell lines, the use of better-controlled culture media, a better understanding of cell metabolism, the expert application of PAT methods or the fine modeling of transport phenomena in the bioreactor.
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Conclusion
Bibliography
Websites
LEEM study. Bioproduction in 2008: state of play and recommendations for French attractiveness. http://www.leem.org/dossier/101/etude-bioproduction-en-2008-etat-des-lieux-et-recommandations-pour-l-attractivite-1297.htm
Events (non-exhaustive list)
ESACT Congress, held every two years in Europe http://www.esact.org/meetings_esact.html
Congress of the engineering foundation: cell culture engineering, held every two years, mainly in the U.S.
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Organizations – Federations – Associations (non-exhaustive list)
ESACT Association: European Society of Animal Cell Technology http://www.esact.org/
Association ACTIP: Animal Cell Technology Industrial Platform http://www.actip.org/
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