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4. Bioreactors for mass culture of animal cells
Whatever the scale used, the bioreactor must enable animal cells to be cultured under controlled physico-chemical environmental conditions (temperature, pH, p O2 ). It must also provide sufficient aeration for the cells, agitation for the suspension of free cells or cells adhered to micro-supports, good levels of material transfer (oxygen and nutrients) and the shortest possible mixing times to ensure correct regulation of operating parameters. In this sense, industrial animal cell culture reactors, based on stirred and aerated tanks, have strong similarities with microbial fermenters, but are used under much less intense stirring and aeration operating conditions.
4.1 Cytoculteurs technologies
Animal cell culture...
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Bioreactors for mass culture of animal cells
Hydrodynamics and material transfer in cytocultivators
Bibliography
Websites
LEEM study. Bioproduction in 2008: state of play and recommendations for French attractiveness. http://www.leem.org/dossier/101/etude-bioproduction-en-2008-etat-des-lieux-et-recommandations-pour-l-attractivite-1297.htm
Events (non-exhaustive list)
ESACT Congress, held every two years in Europe http://www.esact.org/meetings_esact.html
Congress of the engineering foundation: cell culture engineering, held every two years, mainly in the U.S.
Directory
Organizations – Federations – Associations (non-exhaustive list)
ESACT Association: European Society of Animal Cell Technology http://www.esact.org/
Association ACTIP: Animal Cell Technology Industrial Platform http://www.actip.org/
Training courses...
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