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Article | REF: PHA1007 V1

Preferred chemical structures for therapeutic activities

Author: Pascal COUDERT

Publication date: September 10, 2014

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9. Phenothiazines and their structural analogues

The discovery of drugs active in the central nervous system is linked to the history of phenothiazines, tricyclic compounds with a central parathiazine ring and 2 fused benzene rings. One of the first phenothiazines to be used therapeutically was promethazine in 1946 for its antihistaminic properties (figure 15 ).

Ancestry of anti-histamines and tricyclic psychotropics
Figure 15...
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Phenothiazines and their structural analogues
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