3. Production of astatine-211-labeled radiopharmaceuticals

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3.1 Radiolabeling chemistry with astatine-211

It was soon observed that the radiochemical synthesis methods classically used to radiolabel compounds with iodine radioisotopes could also be employed with astatine, in particular for the formation of carbon-halogen bonds. Radiolabeling approaches involving the formation of an astate-carbon covalent bond have enabled the creation of many compounds of interest for ²¹¹ At delivery. However, because the stability of this binding mode is sometimes insufficient, investigations are underway to propose more suitable alternatives for future use in patients.

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Production of astatine-211-labeled radiopharmaceuticals

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Medical applications of astatine-211 in nuclear oncology

Bibliography

(1) - POUGET (J.P.), LOZZA (C.), DESHAYES (E.), BOUDOUSQ (V.), NAVARRO-TEULON (I.) - Introduction to radiobiology of targeted radionuclide therapy. - Frontiers in Medicine, 2 (2015).
(2) - POUGET (J.-P.), NAVARRO-TEULON (I.), BARDIÈS (M.), CHOUIN...

Websites

Nuclear Oncology Research Team http://www.crcina.org

Cyclotron Arronax http://www.cyclotron-nantes.fr

IRSN: knowledge base on radioactivity http://www.irsn.fr

Events

International symposium on radiopharmaceutical sciences. Held every two years. http://www.srsweb.org/meetings/

European symposium on radiopharmacy and radiopharmaceuticals. Held every two years in April. http://www.esrr.info/

Congress of...

Regulations

Institut de Radioprotection et de Sûreté Nucléaire (IRSN): institute covering all risks associated with ionizing radiation used in industry and medicine, as well as natural radiation. http://www.irsn.fr