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5. Conclusion
Due to its almost ideal physical properties for association with both small peptide-like vectors and larger molecules such as antibodies, astatine has a potentially broad spectrum of applications for vectorized radiotherapy of microtumors and hematological cancers. Developments in the use of this radionuclide have long been slow, due to its limited worldwide availability. However, the announced increase in the number of particle gas pedals with the characteristics required for its production should stimulate research at both fundamental and clinical application levels. A major challenge will be to gain a better understanding of the chemical characteristics of the element astatine, so as to be able to propose robust and straightforward routes to radiolabeled vectors for the preparation of radiopharmaceuticals for clinical use. One of the limitations of current approaches will also have to...
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Conclusion
Glossary
Bibliography
Bibliography
Websites
Nuclear Oncology Research Team http://www.crcina.org
Cyclotron Arronax http://www.cyclotron-nantes.fr
IRSN: knowledge base on radioactivity http://www.irsn.fr
Events
International symposium on radiopharmaceutical sciences. Held every two years. http://www.srsweb.org/meetings/
European symposium on radiopharmacy and radiopharmaceuticals. Held every two years in April. http://www.esrr.info/
Congress of...
Regulations
Institut de Radioprotection et de Sûreté Nucléaire (IRSN): institute covering all risks associated with ionizing radiation used in industry and medicine, as well as natural radiation. http://www.irsn.fr
Patents
Process for isolation and purification of astatine-211. United States Patent Application: 0160053345.
Method of producing radionuclides and apparatus therefore. WO/2018/007643
Method for synthesizing iodo- or astatoarenes using diaryliodonium salts. WO/2017/089492
Directory
Manufacturers – Suppliers – Distributors (non-exhaustive list)
Astate-211. Arronax cyclotron, Saint-Herblain http://www.cyclotron-nantes.fr
Tubular furnace for astatine distillation. Verder France, Carbolite Division [email protected]
Organizations – Federations...
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