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4. Medical applications of astatine-211 in nuclear oncology
4.1 Animal studies
As radioactive iodine can be used alone in the form of iodide for thyroid imaging or thyroid tumor therapy, due to its strong tropism for this organ, a number of studies initially focused on the use of injected 211-astatine alone for thyroid treatments, as astatine also accumulates in the thyroid . However, as astatine also accumulates in other organs (stomach, spleen, lung, etc.), and due to the high toxicity of its alpha emissions, these approaches were quickly abandoned. The association with a vector specific to the pathology...
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Medical applications of astatine-211 in nuclear oncology
Conclusion
Bibliography
Bibliography
Websites
Nuclear Oncology Research Team http://www.crcina.org
Cyclotron Arronax http://www.cyclotron-nantes.fr
IRSN: knowledge base on radioactivity http://www.irsn.fr
Events
International symposium on radiopharmaceutical sciences. Held every two years. http://www.srsweb.org/meetings/
European symposium on radiopharmacy and radiopharmaceuticals. Held every two years in April. http://www.esrr.info/
Congress of...
Regulations
Institut de Radioprotection et de Sûreté Nucléaire (IRSN): institute covering all risks associated with ionizing radiation used in industry and medicine, as well as natural radiation. http://www.irsn.fr
Patents
Process for isolation and purification of astatine-211. United States Patent Application: 0160053345.
Method of producing radionuclides and apparatus therefore. WO/2018/007643
Method for synthesizing iodo- or astatoarenes using diaryliodonium salts. WO/2017/089492
Directory
Manufacturers – Suppliers – Distributors (non-exhaustive list)
Astate-211. Arronax cyclotron, Saint-Herblain http://www.cyclotron-nantes.fr
Tubular furnace for astatine distillation. Verder France, Carbolite Division [email protected]
Organizations – Federations...
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