Article | REF: PHA2016 V2

Semi-solid dosage forms

Authors: Marie-Alexandrine BOLZINGER, Stéphanie BRIANÇON, Yves CHEVALIER, Marie-Emmanuelle MILLION

Publication date: March 10, 2023

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6. Ointments

Ointments are made up of a single-phase base in which liquid or solid active ingredients are solubilized or dispersed. They can be hydrophobic or hydrophilic, depending on the nature of the base used. There are also water-absorbing ointments, which are in fact emulsions. They are packaged in single- or multi-dose containers.

6.1 Hydrophobic ointments

According to monograph 07/2021:0132, hydrophobic ointments can only absorb small quantities of water. The most commonly used bases for formulating such ointments are solid kerosene, liquid kerosene, light liquid kerosene, vegetable oils, animal fats, synthetic glycerides, waxes and liquid polyalkylsiloxanes. Their hydrophobic nature gives them occlusive properties, forming a barrier on the skin's surface, limiting...

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