Article | REF: PHA2016 V2

Semi-solid dosage forms

Authors: Marie-Alexandrine BOLZINGER, Stéphanie BRIANÇON, Yves CHEVALIER, Marie-Emmanuelle MILLION

Publication date: March 10, 2023

You do not have access to this resource.
Click here to request your free trial access!

Already subscribed? Log in!


Français

10. Conclusion

Pasty or semi-solid systems for topical administration are highly complex, due to their particular rheological properties and the constraints of pharmaceutical application. These constraints are both technical and regulatory, and reference is always made to the European Pharmacopoeia in this sector.

Semi-solid products come in a wide variety of forms. Their solid consistency at rest is ensured by the continuous network formed by consistency agents: thickeners, gelling agents, particles in concentrated suspension. However, flow is possible by destructuring the network through the application of mechanical stress above the flow threshold. The term semi-solid describes this dual rheological property: solid at rest and fluid under flow. Active substance diffusion is nevertheless possible, as the semi-solid network macroscopically immobilizes a medium that remains liquid...

You do not have access to this resource.

Exclusive to subscribers. 97% yet to be discovered!

You do not have access to this resource.
Click here to request your free trial access!

Already subscribed? Log in!


The Ultimate Scientific and Technical Reference

A Comprehensive Knowledge Base, with over 1,200 authors and 100 scientific advisors
+ More than 10,000 articles and 1,000 how-to sheets, over 800 new or updated articles every year
From design to prototyping, right through to industrialization, the reference for securing the development of your industrial projects

This article is included in

Formulation

This offer includes:

Knowledge Base

Updated and enriched with articles validated by our scientific committees

Services

A set of exclusive tools to complement the resources

Practical Path

Operational and didactic, to guarantee the acquisition of transversal skills

Doc & Quiz

Interactive articles with quizzes, for constructive reading

Subscribe now!

Ongoing reading
Conclusion
Outline