Article | REF: IN404 V1

Artificial Diels-Alderases at the service of green chemistry

Authors: Wadih Ghattas, Jean-Pierre Mahy, Rémy Ricoux, A. Jalila Simaan, Marius Réglier

Publication date: September 10, 2021

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3. Biocatalyzed Diels-Alder cycloaddition reaction

Until the end of the last century, DA reactions seemed to exist only in the field of synthetic chemistry. But in 2000, Vederas and Watanabe described for the first time in the literature two multifunctional enzymes exhibiting diels-alderase (DAase) activities. It wasn't until 2011 that the first true DAase, SpnF, was discovered by Liu's group

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