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ABSTRACT
In the last years, many efforts have been dedicated to demonstrate the potential of carbon nanotubes (CNTs) in the biomedical field. In order to integrate CNTs into living systems and fully exploit their properties, the chemical functionalisation of their surface is a fundamental step. We have proven that only a chemical modification allowing to introduce functional groups capable to disaggregate and shorten the nanotubes can alleviate the possible toxicity risks similar to those induced by long asbestos fibres, to which CNTs have been compared.
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Read the articleAUTHORS
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Cécilia MENARD-MOYON: CNRS Research Associate - Institut de Biologie Moléculaire et Cellulaire, Immunopathology and Therapeutic Chemistry Laboratory, Strasbourg, France
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Alberto BIANCO: CNRS Research Director - Institute of Molecular and Cellular Biology, Immunopathology and Therapeutic Chemistry Laboratory
INTRODUCTION
Area: Nanomaterials/Nanomedicine
Degree of technology diffusion: Emergence | Growth | Maturity
Technologies involved: Chemical functionalization, electron microscopy, imaging techniques
Applications: Development of carbon nanotubes for therapeutic, imaging and diagnostic applications.
Main French players :
Centers of expertise: Immunopathology and Therapeutic Chemistry Laboratory, CNRS Strasbourg
Competitive clusters: Alsace BioValley
Other international players: University of Trieste, Department of Chemical and Pharmaceutical Sciences, Trieste, Italy ; University of Edinburgh, MRC, Edinburgh, UK ; University of Sassari, Department of Chemistry and Pharmacy, Sassari, Italy ; Department of Chemistry, Stanford University, USA ; Memorial Sloan-Kettering Cancer Center, New York, USA
Contact: [email protected] Website: https://ibmc.cnrs.fr/
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KEYWORDS
carbon nanotubes | functionalisation | biodistribution | elimination | toxicity | asbestos fibres
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Carbon nanotube toxicity mitigation through chemical functionalization
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Bibliography
Patents
BIANCO (A.), PANTAROTTO (D.), KOSTARELOS (K.), PRATO (M.). – Non-covalent complexes comprising carbon nanotubes. US patent n° 7858648 B2.
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