Article | REF: IN167 V1

Carbon nanotube toxicity mitigation through chemical functionalization

Authors: Cécilia MENARD-MOYON, Alberto BIANCO

Publication date: January 10, 2014

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ABSTRACT

In the last years, many efforts have been dedicated to demonstrate the potential of carbon nanotubes (CNTs) in the biomedical field. In order to integrate CNTs into living systems and fully exploit their properties, the chemical functionalisation of their surface is a fundamental step. We have proven that only a chemical modification allowing to introduce functional groups capable to disaggregate and shorten the nanotubes can alleviate the possible toxicity risks similar to those induced by long asbestos fibres, to which CNTs have been compared.

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AUTHORS

  • Cécilia MENARD-MOYON: CNRS Research Associate - Institut de Biologie Moléculaire et Cellulaire, Immunopathology and Therapeutic Chemistry Laboratory, Strasbourg, France

  • Alberto BIANCO: CNRS Research Director - Institute of Molecular and Cellular Biology, Immunopathology and Therapeutic Chemistry Laboratory

 INTRODUCTION

Key points

Area: Nanomaterials/Nanomedicine

Degree of technology diffusion: Emergence | Growth | Maturity

Technologies involved: Chemical functionalization, electron microscopy, imaging techniques

Applications: Development of carbon nanotubes for therapeutic, imaging and diagnostic applications.

Main French players :

Centers of expertise: Immunopathology and Therapeutic Chemistry Laboratory, CNRS Strasbourg

Competitive clusters: Alsace BioValley

Other international players: University of Trieste, Department of Chemical and Pharmaceutical Sciences, Trieste, Italy ; University of Edinburgh, MRC, Edinburgh, UK ; University of Sassari, Department of Chemistry and Pharmacy, Sassari, Italy ; Department of Chemistry, Stanford University, USA ; Memorial Sloan-Kettering Cancer Center, New York, USA

Contact: [email protected] Website: https://ibmc.cnrs.fr/

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Carbon nanotube toxicity mitigation through chemical functionalization