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Article | REF: P1457 V1

Two-dimensional liquid chromatography (2D-LC)

Authors: Sabine HEINISCH, Morgan SARRUT

Publication date: August 10, 2020

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4. 2D-LC applications

2D-LC is applied in a wide variety of fields, including pharmaceuticals, agrifoods, specialty chemicals/synthetic polymers, energy and the environment . The growth of this technique is particularly significant in the biopharmaceutical sector, where it is essential to finely characterize highly complex proteins (such as monoclonal antibodies or conjugated antibodies) whose very diverse properties (size, charge, hydrophobicity, hydrophilicity, presence of glycans, etc.) lend themselves particularly well to multidimensional analysis

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