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4. Quality assurance of HPLC-ICP-MS analyses
As with any analytical method, rigorous quality assurance is essential for HPLC-ICP-MS assays. This is all the more important as the number of standards describing the use of this coupling is still low.
The methods developed must be fully mastered, both in terms of species separation and detection. General validation criteria such as limit of detection/limit of quantification, linearity, accuracy, precision and robustness must be assessed. Given the low levels of species generally measured, contamination by blank analysis must be assessed; their level must be as low as possible in order to obtain good performance in terms of sensitivity. In addition, evaluation of detection/quantification limits and linearity requires calibration with solutions containing the chemical form(s) to be analyzed. Certified standard solutions are currently available on the market for...
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Quality assurance of HPLC-ICP-MS analyses
Conclusion
Bibliography
Standards and norms
- Food products – Determining elements and their chemical forms – Determination of inorganic arsenic content in food products of marine and plant origin, by HPLC with anion exchange and inductively coupled plasma mass spectrometry (ICP-MS) - NF EN 16802 - 2016
- Water quality – Determination of arsenic chemical forms (III) and (V) – Method using high-performance liquid chromatography (HPLC) with detection by plasma...
Regulations
European Commission Regulation (EC) No 2015/1006 of 25 June 2015 amending Regulation (EC) No 1881/2006 as regards maximum levels for inorganic arsenic in foodstuffs setting maximum levels for certain contaminants in foodstuffs (OJ L. 161, 26/6/2015, p. 14-16)
Directive 2000/53/EC of the European Parliament and of the Council of 27 January 2003 on end-of-life vehicles (OJ L. 269 of 21/10/2000, pp. 34-43)...
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Manufacturers – Suppliers – Distributors (non-exhaustive list)
Agilent Technologies http://www.agilent.com
Analytik Jena http://www.analytik-jena.de
Cameca
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