1. Raw materials for suppository manufacture
Rectal forms are among the oldest pharmaceutical forms, since their use dates back to antiquity, with mentions in the Old Testament and the texts of Hippocrates. The first rectal form was the enema, followed by the suppository, whose name comes from the Latin supponere, meaning "in place of" the enema. The first suppositories consisted of solid forms (horn, cooked honey, acorn, etc.) impregnated with medicinal preparations. However, it wasn't until the 19th century that the suppository form became a truly modern pharmaceutical form, using cocoa butter as a carrier and then introducing the active substance into the melted preparation before molding.
The raw materials used to manufacture suppositories must have certain properties adapted to the characteristics of the rectal ampoule:
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Raw materials for suppository manufacture
Suppository formulation
Bibliography
Websites
GATTEFOSSE, Hemisynthetic glycerides for suppositories and ovules with solid or liquid active ingredients, Internet http://www.gattefosse.com/fr/applications/?voie-d-administration,rectale-et-vaginale (page consultée le 11/06/2013)
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Norms and standards
- Classification biophamarceutique BCS - Pharmacopée Européenne 7.0 - . 2012
Patents
STEVENSON (W.G) and MACKINNON (W.E.) (5-2-1952) US Patent US 2,584,166, Deposited it 25-5-1948, Suppository.
SCHLUETER (K.W.) and SCHULTZ-KAISER (E.) (24-4-1979) US Patent US 4,151,274, Deposited it 15-11-1976, Process and composition for the production of suppositories.
GOYAN (J.E.) and WRABLE (M.) (14-3-1961) US Patent US 2,975,099, Deposited it 25-6-1958, Polyethylene glycol...
Directory
Manufacturers – Suppliers – Distributors (non-exhaustive list)
Dow for polyethylene glycols http://www.dow.com/polyglycols/polyethylene/products/carbowaxp.htm
Gattefossé for suppositories http://www.gattefosse.com/fr/applications/?voie-d-administration, rectal and vaginal masses
Cremer oleo for suppository masses http://www.cremeroleo.de/en/produktbereiche/cremer-health/index.php...
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