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2. Suppository formulation
2.1 Raw material selection criteria
As we have already seen, suppository masses are made up of lipophilic or water-soluble products that dissolve in the rectal ampoule. The choice of one or other of these categories depends on the properties of the active ingredient chosen for the targeted therapeutic application.
The solubility of the active ingredient is generally a major criterion in the choice of suppository mass. For example, hydrophilic active ingredients can be formulated in lipophilic suppository masses, while lipophilic active ingredients can be formulated in hydrophilic masses. In both cases, the suppository enables dispersion of the active ingredient in the rectal ampoule and facilitates its release.
Most rectal active ingredients...
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Suppository formulation
Manufacturing techniques
Bibliography
Websites
GATTEFOSSE, Hemisynthetic glycerides for suppositories and ovules with solid or liquid active ingredients, Internet http://www.gattefosse.com/fr/applications/?voie-d-administration,rectale-et-vaginale (page consultée le 11/06/2013)
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Norms and standards
- Classification biophamarceutique BCS - Pharmacopée Européenne 7.0 - . 2012
Patents
STEVENSON (W.G) and MACKINNON (W.E.) (5-2-1952) US Patent US 2,584,166, Deposited it 25-5-1948, Suppository.
SCHLUETER (K.W.) and SCHULTZ-KAISER (E.) (24-4-1979) US Patent US 4,151,274, Deposited it 15-11-1976, Process and composition for the production of suppositories.
GOYAN (J.E.) and WRABLE (M.) (14-3-1961) US Patent US 2,975,099, Deposited it 25-6-1958, Polyethylene glycol...
Directory
Manufacturers – Suppliers – Distributors (non-exhaustive list)
Dow for polyethylene glycols http://www.dow.com/polyglycols/polyethylene/products/carbowaxp.htm
Gattefossé for suppositories http://www.gattefosse.com/fr/applications/?voie-d-administration, rectal and vaginal masses
Cremer oleo for suppository masses http://www.cremeroleo.de/en/produktbereiche/cremer-health/index.php...
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