7. Conclusion
Our intimate understanding of embryogenesis and bone repair has enabled us to identify key cellular (MSCs) and molecular (BMPs) effectors for bone repair. The combination of these effectors with matrices enabling their delivery has given rise to a new generation of materials whose ambition is not only to repair the deficient mechanical function of bone tissue, but also to achieve its repair ad integrum. While these tissue-engineered products are likely to offer far superior therapeutic efficacy to conventional biomaterials in the long term, further development is still required to satisfactorily deliver their biological component. For example, optimal use of BMPs requires the development of carriers that allow both their confinement to the injured site and their delivery at effective doses for a sufficiently long time. Similarly, rational use of stem cells requires the development of materials...
The Ultimate Scientific and Technical Reference
This article is included in
Healthcare technologies
This offer includes:
Knowledge Base
Updated and enriched with articles validated by our scientific committees
Services
A set of exclusive tools to complement the resources
Practical Path
Operational and didactic, to guarantee the acquisition of transversal skills
Doc & Quiz
Interactive articles with quizzes, for constructive reading
Conclusion
Glossary – Definitions
Bibliography
Websites
Haute Autorité de Santé for the evaluation of bone substitutes http://www.has-sante.fr/portail/upload/docs/application/pdf/2013.06/rapport_devaluation_des_substituts_osseux.pdf
Events
European Society for Biomaterials http://www.esbiomaterials.eu/
French Society of Orthopaedic and Traumatological Surgery http://www.sofcot.fr/
Standards and norms
- Norme sur l'évaluation biologique des dispositifs médicaux - NF EN ISO 10993-1 -
Regulations
Article L. 1243-2 of the French Public Health Code: "The preparation, preservation, distribution and transfer, for autologous or allogeneic therapeutic purposes, of tissues and their derivatives and cell therapy preparations may be carried out by establishments and organizations authorized for this purpose, after consultation with the Agence de la biomédecine, by the Agence nationale de sécurité du médicament et des produits...
Directory
Laboratories – Design offices – Schools – Research centers (non-exhaustive list)
École des mines de Saint-Étienne http://www.ism.univmed.fr
Institute of Movement Sciences http://www.ism.univmed.fr
Osteoarticular Bioengineering...
The Ultimate Scientific and Technical Reference
