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4. Bone substitutes
The complications associated with autograft bone harvesting, as well as the potential infectious and immunological risks of allografts, have prompted the development of bone substitutes as alternatives to bone grafts. The Société francaise de chirurgie orthopédique et traumatologique (SOFCOT) proposes that bone substitutes be defined as :
"Any biomaterial of human, plant or synthetic origin (i) intended for implantation in humans; (ii) with a view to reconstituting bone stock; (iii) by reinforcing a bone structure or filling a loss of bone substance of traumatic or orthopedic origin".
These bone substitutes are used in a wide range of pathologies involving orthopedic, cranio-maxillofacial and reconstructive, stomatological, otorhinolaryngological and dental surgery, where the loss of substance may be traumatic, tumoral or degenerative in...
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Bone substitutes
Regenerating bone tissue with bone morphogenesis proteins
Bibliography
Websites
Haute Autorité de Santé for the evaluation of bone substitutes http://www.has-sante.fr/portail/upload/docs/application/pdf/2013.06/rapport_devaluation_des_substituts_osseux.pdf
Events
European Society for Biomaterials http://www.esbiomaterials.eu/
French Society of Orthopaedic and Traumatological Surgery http://www.sofcot.fr/
Standards and norms
- Norme sur l'évaluation biologique des dispositifs médicaux - NF EN ISO 10993-1 -
Regulations
Article L. 1243-2 of the French Public Health Code: "The preparation, preservation, distribution and transfer, for autologous or allogeneic therapeutic purposes, of tissues and their derivatives and cell therapy preparations may be carried out by establishments and organizations authorized for this purpose, after consultation with the Agence de la biomédecine, by the Agence nationale de sécurité du médicament et des produits...
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