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Article | REF: MED7150 V1

Collagen-based biomaterials for health applications

Authors: Cécile ECHALIER, Ahmad MEHDI, Jean MARTINEZ, Gilles SUBRA

Publication date: May 10, 2018 | Lire en français

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    1. Multiscale structure and biological role of collagen

    Collagen is the most abundant protein in the human body, and the main component of the extracellular matrix. Collagen fibers give tissues mechanical resistance to stretching.

    In biological tissues, cells are surrounded by a complex, bioactive matrix - the extracellular matrix. It provides mechanical support to cells, while regulating their behavior. It is involved in cell survival, proliferation, migration and differentiation. The composition of this matrix varies from one tissue to another, but overall it consists of an interstitial fluid held together by a three-dimensional network of hydrated proteoglycans (polysaccharides attached to a central protein) and fibrous proteins, of which collagen is the most abundant.

    Strictly speaking, collagen does not refer to a single protein, but to a family...

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