Overview
FrançaisABSTRACT
Calcium phosphate cements are biomaterials whose development requires control of several properties (setting time, injectability, mechanical properties...). These new bone substitutes can release in situ compounds of biological interest to conduct bone formation in healthy bone site but also in pathological situations. In this paper, special attention will be paid to a new approach for a preventive treatment of osteoporosis.
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Read the articleAUTHORS
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Pascal JANVIER: Senior Lecturer, UFR des Sciences et Techniques - CEISAM CNRS UMR 6230 Laboratory, University of Nantes, France
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Élise VERRON: Senior Lecturer, UFR of Pharmaceutical and Biological Sciences - LIOAD Laboratory INSERM U791, University of Nantes, France
INTRODUCTION
20 years ago, the use of bone cement in orthopaedic surgery meant referring only to a synthetic acrylic resin resulting from the polymerization of methyl methacrylate. The mechanical properties of these cements mean that they can be used to fix prostheses or fill vertebral defects. However, their physico-chemical characteristics remain far removed from the biological environment of their implantation site, which is why researchers and practitioners have been developing calcium phosphate (CaP)-based bone substitutes for several decades, whose chemical composition is close to that of bone and which can therefore also undergo the natural bone remodeling cycle.
Initially used as bioceramics, these bone substitutes in the form of self-curing in vivo cement fundamentally broaden therapeutic indications by enabling these bioactive substitutes to adapt perfectly to the bone defects to be filled. This has, however, presented new challenges for these bioactive biomaterials in terms of injectability, setting time and mechanical strength. These cements have already proved their worth in orthopedic and dental surgery, but some of their properties still need to be improved. A new challenge is to use these phosphocalcic cements as carriers of active ingredients to provide a therapeutic response in clinical contexts deemed critical (osteoporosis, infection, inflammation, irradiation...). After reviewing the general context of bone-filling cements, this article focuses on the phosphocalcic cements currently in use, as well as on new generations of these derivatives.
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KEYWORDS
biomaterial | phosphocalcic cement | bone substitute
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Cements for filling bone defects
Bibliography
Websites
Maîtrise orthopédique – the orthopaedic journal http://www.maitrise-orthop.com/
French Society of Orthopaedic and Traumatological Surgery http://www.sofcot.fr/
"Biomat" brings together many international links in the biomaterials field....
Events
Annual GRIBOI conference brings together all professionals involved in injectable biomaterials http://www.griboi.org/
Standards and norms
- Surgical implants – hydroxyapatite – Part 3: Chemical analysis and characterization of crystallinity and phase purity - NF ISO 13779-3 - 04-08
- Biological evaluation of medical devices – Part 1: Assessment and testing as part of a risk management process - NF ISO 10993-1 - 07-10
- Biological evaluation of medical devices – Part 6: Tests for local effects after implantation - NF ISO 10993-6 - 12-09
- Biological...
Patents
Injectable calcium-phosphate cement releasing a bone resorption inhibitor. WO 2008098959
Analgesic apatitic calcium-phosphate cement patent n° 08290010.1-1219
Modified calcium phosphate compound, injectable compound containing it WO 03074098
Gallium-doped phosphocalcic compounds patent n° 093505194.4 – 2111
Gallium-doped phosphocalcic...
Directory
Osteo-Articular and Dental Engineering Laboratory (LIOAD), UMR INSERM U 791, University of Nantes, Odontology Faculty, Nantes http://lioad.nantes.inserm.fr/index.php/fr/
Laboratoire de Chimie et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), UMR CNRS 6230, Université de Nantes, UFR Sciences et Techniques,...
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