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4. Conclusion
Phosphocalcic cements combined with active molecules are currently very popular in bone reconstruction surgery, whether to reinforce the stability of prostheses, prevent the risk of bone infections, or prevent the recurrence of osteolytic tumors.
These systems are also being considered to enhance the osteogenic potential of conventional bone substitutes, notably by incorporating hormones and growth factors such as BMP-2. However, these proteins are fragile and could generate deleterious side effects. Targeted vectorization of their encoding DNA is one way of enabling these factors to be synthesized in situ without being degraded.
Research is also moving towards the development of a new generation of combined biomaterials in which osteoprogenitor cells would be added to these growth factors to recreate a microenvironment conducive to bone...
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Conclusion
Bibliography
Websites
Maîtrise orthopédique – the orthopaedic journal http://www.maitrise-orthop.com/
French Society of Orthopaedic and Traumatological Surgery http://www.sofcot.fr/
"Biomat" brings together many international links in the biomaterials field....
Events
Annual GRIBOI conference brings together all professionals involved in injectable biomaterials http://www.griboi.org/
Standards and norms
- Surgical implants – hydroxyapatite – Part 3: Chemical analysis and characterization of crystallinity and phase purity - NF ISO 13779-3 - 04-08
- Biological evaluation of medical devices – Part 1: Assessment and testing as part of a risk management process - NF ISO 10993-1 - 07-10
- Biological evaluation of medical devices – Part 6: Tests for local effects after implantation - NF ISO 10993-6 - 12-09
- Biological...
Patents
Injectable calcium-phosphate cement releasing a bone resorption inhibitor. WO 2008098959
Analgesic apatitic calcium-phosphate cement patent n° 08290010.1-1219
Modified calcium phosphate compound, injectable compound containing it WO 03074098
Gallium-doped phosphocalcic compounds patent n° 093505194.4 – 2111
Gallium-doped phosphocalcic...
Directory
Osteo-Articular and Dental Engineering Laboratory (LIOAD), UMR INSERM U 791, University of Nantes, Odontology Faculty, Nantes http://lioad.nantes.inserm.fr/index.php/fr/
Laboratoire de Chimie et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), UMR CNRS 6230, Université de Nantes, UFR Sciences et Techniques,...
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