Article | REF: MED1500 V1

Lasers in medicine

Author: Serge MORDON

Publication date: October 10, 2013

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ABSTRACT

Since their invention, lasers have been considered as potentially interesting light sources for medicine. Thanks to the possibility of obtaining a specific wavelength and a continuous or pulsed emission, different modes of action on biological tissues can be obtained. Four effects are usually distinguished: photomechanical, photoablative, thermal and photodynamic. Various medical disciplines thus use lasers in order to obtain such effects.

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 INTRODUCTION

Medicine has seen many advances, thanks in particular to the use of new methods and tools. In fact, the laser alone is a method and a tool that has enabled a veritable revolution in many fields, including medicine. LASER is an acronym for "Light Amplification by Simulated Emission of Radiation". The laser produces a coherent collimated light beam through the process of stimulated emission. Thanks to the possibility of obtaining a specific wavelength and continuous or pulsed emission, different modes of action on biological tissues can be obtained; four effects are usually distinguished: photomechanical, photoablative, thermal and photodynamic. To understand and control the therapeutic effect at a given tissue location, we need to know the amount of energy deposited there by the laser beam. This depends not only on the irradiation parameters characterizing the laser source (power, beam diameter, wavelength, repetition rate and energy per pulse for a pulsed laser), which are known and controlled, but also on the optical properties of the biological tissue. Today, lasers are used in many medical disciplines. Once the optical mechanisms in biological tissue have been defined, this article will describe each of these effects and illustrate them with a few medical applications.

History

Since their invention in 1960, lasers have appeared as potentially interesting light sources for medicine, as they possess three characteristics that distinguish them from conventional sources: directivity, the ability to operate in pulse mode with very short durations, and monochromaticity. This last property is probably the least useful in medicine, since biological molecules have a broad absorption spectrum, and their activation does not require a spectrally narrow source.

Medical applications were soon found for this new instrument. The ruby laser was used as early as 1961 by Campbell in ophthalmology and in 1963 by Goldman in dermatology. The ionized argon laser (488-514 nm) soon became the laser of choice for the treatment of retinal detachment. The carbon dioxide laser (CO 2 ), introduced by Polanyi and Kaplan in 1965 and 1967, was first offered to surgeons with the concept of an "optical" scalpel. It has since been used in a wide range of indications, particularly in dermatology. The use of fiber optics in the 1970s opened up the field of endocavitary laser applications, thanks to the possibility of introducing the fiber into the operating channel of an endoscope. Here again, the argon laser (Dwyer in 1975), but above all the Nd:YAG laser (Kiefhaber in 1975), were used in gastroenterology, pneumology and other fields. In 1976, Hofstetter used the laser for the first time in urology. Thanks to...

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