Article | REF: J2312 V1

Sunscreens Formulation and efficacy testing

Authors: Céline COUTEAU, Laurence COIFFARD

Publication date: March 10, 2018, Review date: September 2, 2020

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Overview

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ABSTRACT

Sunscreens are a useful part of a global strategy of skin sun protection. They are cosmetic products according to Regulation (EC) No1223/2009. They appeared on the market in the 1930s since when their composition has never ceased to change. The article first gives some definitions and then recalls some regulations. It details the role of sunscreens, their composition and particularly the choice of filters by the formulator. Finally, the methods used to determine their efficacy are described.

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AUTHORS

  • Céline COUTEAU: Senior lecturer – HDR - University of Nantes – Faculty of Pharmacy – Laboratoire de Pharmacie industrielle et de Cosmétologie – MMS EA 2160 Nantes, France

  • Laurence COIFFARD: Professor - University of Nantes – Faculty of Pharmacy – Laboratoire de Pharmacie industrielle et de Cosmétologie – MMS EA 2160 Nantes, France

 INTRODUCTION

Figures provided by the French National Cancer Institute show that the number of new cases of skin cancer more than tripled between 1980 and 2012. It is highly likely that this situation can be explained by changes in exposure habits to ultraviolet (UV) radiation, whether of natural origin (i.e. solar) or artificial (i.e. via UV cabins), over the last forty years or so. Such exposure is the most important factor in the risk of developing this type of cancer. From a medical point of view, a distinction is made between melanoma and carcinoma. These are the most common type of carcinoma. They generally occur after the age of 50, on exposed areas of the body, and are most often attributed to excessive and chronic sun exposure. Cutaneous melanoma is much rarer than carcinoma, but it should be borne in mind that it is the most serious of all skin cancers, due to the formation of metastases. Between 1980 and 2012, an estimated 14,325 people in France were affected by melanoma, and 1,773 died from it in 2015.

The use of sun protection products (SPPs) plays a key role in the overall strategy for preventing skin cancer, and it is vital to have safe, effective products. This calls for rigorous formulation and reliable methods for determining efficacy.

Historical overview

It took a long time for the harmful effects of sun exposure to become known to the general public and even to scientists. For example, Auguste Rollier (1874 – 1954), convinced by the work of his predecessor Finsen, opened one of the first heliotherapy centers in Leysin, Switzerland, in 1903.

The first sun protection products (SPPs) are relatively recent, dating back only to the 1930s. This was a time of euphoria over paid vacations, when people were unaware of the sun's harmful effects on the skin and wanted, above all, to tan. It's commonplace to attribute much of the bronzed complexion trend to Coco Chanel. It's more likely that the beautiful Josephine Baker, who made her name in 1925 in a show she starred in, "La Revue nègre", played a leading role. Various personalities from the artistic world, such as the poet Jean Cocteau, fell in love with the coppery complexion... and helped to promote what has been called "the joys of tanning", joys that were quite ephemeral compared to the effects that would later be highlighted. If we look at preparations from this period, we see that they were tanning preparations, and the filters most commonly used were derivatives of p-amino-benzoic acid (PABA) and tannic acid. The galenic forms are extremely limited in variety, and almost all are oils.

It was during the Second World War that Red Vet Pet (RVP) was first used, a simple (!) preparation that became part of the soldier's basic...

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KEYWORDS

sun protection factor SPF   |   PF-UVA   |   sun filter


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