Article | REF: NM4025 V1

Multifunctional gold nanoparticles for imaging and therapy

Authors: Gautier LAURENT, Gloria JIMENEZ SANCHEZ, Rana BAZZI, François LUX, Pascal PERRIAT, Olivier TILLEMENT, Stéphane ROUX

Publication date: December 10, 2014

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1. Context

Faced with the difficulty of treating certain types of cancer, original avenues have been explored, drawing on advances in nanoscience and nanotechnology. Since the 2000s, nanoparticles have been the focus of numerous studies aimed at demonstrating their potential to eradicate solid tumors, thanks to their small size and ability to combine multiple complementary properties. By playing on the various physico-chemical parameters of nanoparticles and taking advantage of the particular characteristics of the solid tumor environment, it is possible to design remote-controlled imaging and/or therapy agents. However, while it is now relatively easy to combine different imaging modalities with therapeutic activity, the development of nanoparticles for biomedical applications often stumbles over the control of their behavior after administration (accumulation in the tumor, renal elimination). Among...

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