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1. Supramolecular chemistry of living matter
Supramolecular systems are crucial to the evolution and adaptation of living systems, and what we might call the biological machinery relies heavily on these principles of recognition and self-organization. The chemistry of life is extremely complex, involving macromolecules, covalent entities, or supermolecules, supramolecular assemblies of several covalent entities. The extreme complexity of these supramolecular systems, in terms of both structure and function, has long fascinated and inspired researchers. In this section, we discuss a few simple examples that illustrate both the diversity and complexity of supramolecular systems in biology.
1.1 Self-assemblies and supermolecules of the living world
Whether assemblies of macromolecules such as certain proteins...
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Supramolecular chemistry of living matter
Dynamic combinatorial chemistry (CCD)
Bibliography
Software tools
Visualization of complex molecular structures (proteins, polynucleotides): the NGL Viewer :
AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. Web-based molecular graphics for large complexes. Bioinformatics: bty 419, 2018.doi :10.1093bioinformatics/bty 419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res...
Websites
Theoretical and Computational Biophysics Group at the University of Illinois at Urbana-Champaign (USA):
How enzymes work:
https://pdb101.rcsb.org/learn/videos/how-enzymes-work
...
Events
Symposium: International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC), held annually.
International Conference on Calixarenes, is held every two years.
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