Article | REF: RE209 V1

Optimization of lipid production in yeast by genetic engineering

Authors: Céline BOULARD, Marine FROISSARD

Publication date: February 10, 2012

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AUTHORS

  • Céline BOULARD: French National Institute for Agronomic Research (INRA) - Lipid dynamics and structure team, Institut Jean-Pierre Bourgin (UMR 1318 INRA/AgroParisTech), Versailles

  • Marine FROISSARD: French National Institute for Agronomic Research (INRA) - Lipid dynamics and structure team, Institut Jean-Pierre Bourgin (UMR 1318 INRA/AgroParisTech), Versailles

 INTRODUCTION

Summary: Reducing the use of petroleum-based products in the current economic and ecological context means turning to sustainable, biosourced raw materials. Lipids are key molecules for the production of biodiesel and green chemistry products. Yeast is the cell of choice for custom lipid production. The combination of metabolic engineering and genetic engineering approaches enables the production of these molecules of interest to be optimized. The use of knowledge acquired on lipid storage in plants and in S. cerevisiae is leading to the development of innovative cellular systems for renewable energy production.

Abstract: the decrease of petroleum product usage due to economic and ecologic present context leads to find renewable and durable raw material. Lipids are key molecules for the production of biofuel and green chemistry products. Yeasts are of interest for designed lipid production. The association of metabolic and genetic approaches allows to optimize production of useful molecules. The use of knowledge on lipid storage in plants and in S. cerevisiae leads to develop innovative cell systems for renewable energy production.

Keywords: lipid bodies, green chemistry, biofuels, lipids, biotechnologies, Saccharomyces cerevisiae, Arabidopsis thaliana

Keywords: lipid bodies, green chemistry, biofuel, lipids, biotechnology, Saccharomyces cerevisiae, Arabidopsis thaliana

Key points

Field: energy, biotechnology, lipid biology and biochemistry

Degree of technology diffusion: Emergence / Growth / Maturity

Technologies involved: microscopies, particle analysis, lipid analytical chemistry

Applications: green chemistry and biofuels

Main French players : –

Competitive clusters : –

Competence centers : –

Manufacturers : –

Other players worldwide : –

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Optimization of lipid production in yeast by genetic engineering