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2. Reverse engineering approach
The secondary metabolites most commonly found in marine fungi are polyketides, non-ribosomal peptides and terpenes, which account for around 80% of the natural compounds obtained from these microorganisms . However, these metabolites remain largely inaccessible due to the fact that many biosynthetic pathways are cryptic, i.e. not expressed, or only weakly expressed, under conventional laboratory conditions. Indeed, a bioinformatics analysis of the genome of the species Acremonium chrysogenum, known mainly for its cephalosporin C synthesis, indicates the presence of 38 gene clusters involved in the synthesis of secondary metabolites, of which ~ 52% encode polyketides,...
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Reverse engineering approach
Conclusion
Bibliography
Websites
AntiSMASH, a database used to detect antibiotic production in micro-organisms: https://antismash.secondarymetabolites.org
PRISM, software for predicting secondary metabolites in microorganisms : https://magarveylab.ca/prism/#!/prism
...Events
Sea Tech Week, Marine bioresources and their applications, takes place every year in Brest: http://www.seatechweek.eu/
MaFNaP international conference. Conference on natural products from marine mushrooms, held annually in different European cities.
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