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Article | REF: IN232 V1

Main applications of cyclodextrin/substrate inclusion complexes

Authors: Grégorio CRINI, Sophie FOURMENTIN, Marc FOURMENTIN, Nadia MORIN-CRINI

Publication date: May 10, 2019

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ABSTRACT

Cyclodextrins are cyclic oligosaccharides obtained by the enzymatic degradation of starch. They possess a hydrophobic cavity that allows them to encapsulate other compounds. The formation of such inclusion complexes, also called "host/guest complexes" is likely to modify the physical, chemical and/or biological characteristics of the guest molecule. This article describes the main applications of cyclodextrin/substrate inclusion complexes through several examples published in the literature. All industrial fields are concerned, from pharmaceuticals to cosmetics, through chromatography, food, medical, biotechnology or catalysis.

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AUTHORS

  • Grégorio CRINI: Engineer, qualified to direct research - UMR 6249 Chrono-environnement, University of Burgundy Franche-Comté, Besançon, France

  • Sophie FOURMENTIN: University Professor - Unité de Chimie environnementale et Interactions sur le Vivant, Université du Littoral Côte d'Opale, Dunkerque, France

  • Marc FOURMENTIN: Research engineer - Laboratoire de Physico-chimie de l'Atmosphère, Université du Littoral Côte d'Opale, Dunkerque, France

  • Nadia MORIN-CRINI: Research engineer, qualified to direct research - UMR 6249 Chrono-environnement, University of Burgundy Franche-Comté, Besançon, France

 INTRODUCTION

Although discovered in 1891, cyclodextrins are still of interest from both a fundamental and an industrial point of view. Cyclodextrins are synthetic substances derived from the enzymatic degradation of starch, one of our planet's most important polysaccharides. They feature a hydrophobic cavity within their structure, enabling them to encapsulate various substances. Many developments are based on the concept of complexes formed by association between the host (molecular receptor) and the guest (target molecule, ionic entity). The formation of such complexes is likely to modify and/or enhance the physical, chemical and/or biological characteristics of the enclosed substance. Host/guest chemistry has become an essential branch of molecular recognition.

Thanks to this encapsulation property, cyclodextrins are an important class of molecular receptors used, for example, in the delivery of bioactive compounds, substrate detection and molecular recognition phenomena [NM 221] . Virtually all industrial fields are concerned, from pharmaceuticals and cosmetics to chromatography, food, medicine, hygiene, catalysis and textiles. Other fields, such as medical imaging, nanotechnology, agrochemicals, packaging, the flavor industry and water treatment, are also the focus of much research or development.

The aim of this article is firstly to present cyclodextrin molecules and their properties, and secondly to show the interest in using these molecules in various applications.

Key points

Fields: Chemistry, biology, pharmaceuticals, cosmetology, catalysis, agrochemistry, environment

Degree of technology diffusion: Growth

Technologies involved: Chemical synthesis, scientific instrumentation, nanosciences

Areas of application: Solubilization and vectorization of active ingredients, encapsulation of flavors, chromatographic separations, nanotechnologies, treatment of water, air and polluted soils.

Main French players :

Manufacturers: Roquette, Lestrem: https://roquette.com ; Biocydex, Poitiers: http://.biocydex.net

Other players worldwide :

Industrials: Cyclolab, Budapest, Hungary:...

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KEYWORDS

applications   |   cyclodextrin   |   inclusion complex

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