Français
4. Making a biochip
4.1 The importance of surface chemistry
As mentioned in the introduction, optical biochips require the involvement of several scientific disciplines (microelectronics, chemistry, biology, bioinformatics, optics, etc.). One of the key points in the implementation of biochip systems lies in mastering the production of active biochip surfaces. Indeed, the specifications for these surfaces are relatively restrictive: overall, they must be biochemically inert, except in the active zones forming the measurement pads, where each must be reactive to a specific target. .
In the case of DNA biochips, these pads are functionalized by single-stranded oligonucleotide sequences chosen to recognize complementary oligonucleotide...
The Ultimate Scientific and Technical Reference
This article is included in
Mechanical and dimensional measurements
This offer includes:
Knowledge Base
Updated and enriched with articles validated by our scientific committees
Services
A set of exclusive tools to complement the resources
Practical Path
Operational and didactic, to guarantee the acquisition of transversal skills
Doc & Quiz
Interactive articles with quizzes, for constructive reading
Making a biochip
Spatio-temporal self-calibration of a dynamic biochip
Bibliography
Also in our databaseshttp://www.techniques-ingenieur.fr
Websites to consult
Online catalog http://www.abes.fr/abes/index.html
Theses available online http://tel.archives-ouvertes.fr/
Patent pending
Patent FR n° 05 12 594, "Procédé d'auto-calibration de biopuces" – CNRS (13/12/2005). International extension PCT/EP2006/069683 – (13/12/2006).
Directory
Manufacturers. Suppliers. Distributors (non-exhaustive list)
ACEA Biosciences http://www.aceabio.com/Products/index.htm
Affymetrix http://www.affymetrix.com/index.affx
The Ultimate Scientific and Technical Reference
