Article | REF: P1491 V1

Chromatographic couplings with mass spectrometry. II

Author: Patrick ARPINO

Publication date: March 10, 2008

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5. Quantitative analysis

From the outset, GC-MS has been perceived as a high-performance quantitative assay method [46] . Today, it is widely applied in pharmaceuticals for the determination of drugs and their metabolites, and in forensic science for the detection of fraud, counterfeiting, doping, etc.

5.1 Detection principles

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5.1.1 Electronic ionization detection

An EI-mode MS belongs to the category of chromatographic detectors delivering...

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