Article | REF: J8015 V1

Benchtop NMR spectrometers for the in-line monitoring of continuous flow reactions

Authors: Patrick GIRAUDEAU, François-Xavier FELPIN

Publication date: May 10, 2019

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5. 2D BC NMR reaction monitoring

Naturally, online 19 F NMR tracking is only possible in a limited number of situations where the product of interest carries a fluorine atom. Thus, in the absence of 19 F nuclei and if 1 H spectra prove too complex to analyze, even after solvent exchange (protonated → deuterated), reaction tracking can be carried out using 2-dimensional sequences. The use of 2-D NMR experiments, where resonances are recorded on a 2-D map, makes sense at low fields thanks to a significant gain in signal separation. As such, numerous homo- and heteronuclear sequences, including ultrafast methodologies, have already been developed on low-field benchtop spectrometers as discussed in section II, although not all of these tools have yet been used for monitoring reactions conducted...

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2D BC NMR reaction monitoring