Article | REF: K1220 V1

Chemistry without solvents

Authors: Pierrick NUN, Evelina COLACINO, Jean MARTINEZ, Frédéric LAMATY, Max MALACRIA, Jean-Philippe GODDARD, Cyril OLLIVIER

Publication date: November 10, 2008

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4. Industrial applications

Numerous studies at laboratory, pilot or production scale have been financed by industry. For reasons of intellectual property, in most cases, given their interest and importance, they have not been published. As a result, possible sources for solvent-free processes at industrial level are difficult to access. However, a few examples have been listed in the literature.

4.1 Classic methods

  • The synthesis of cyanotrimethylsilane (Me 3 SiCN, melting point 11 °C) was carried out on a batch scale of 810 kg in a pilot plant, without solvent by silylation reaction of hydrocyanic acid (HCN) in the presence of hexamethyldisilazane (HMDS) according to :

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