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1. Synthesis of isonitriles
The first isonitrile was obtained by treating allyl bromide with silver cyanide (figure 1 ) [1]. This synthesis is virtually no longer used today, and isonitriles are mainly prepared by two methods: either directly from amines and chloroform in a basic medium (carbylamine reaction) or by dehydration of formamides.
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Synthesis of isonitriles
General reactivity
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