Article | REF: CHV2200 V1

Isonitriles and multicomponent reactions

Authors: Laurent EL KAIM, Jieping ZHU

Publication date: May 10, 2010, Review date: October 25, 2017

You do not have access to this resource.
Click here to request your free trial access!

Already subscribed? Log in!


Français

7. MCR and functionalized isonitriles

7.1 Toluene sulfonyl methyl isonitrile

The chemistry of toluene sulfonyl methyl isonitrile (TosMIC) and its derivatives has been extensively studied by Van Leusen's team [133]. The presence of two electron-withdrawing groups on the same carbon greatly increases the acidity of these compounds. After deprotonation by weak bases, the carbanion formed can then react with various electrophiles. The use of polarized double bonds such as imines and carbonyl compounds can lead to heterocycles via an aldolization (or Mannich reaction)/cyclization/prototropy/β-elimination sequence (figure 72 ) [134].

You do not have access to this resource.

Exclusive to subscribers. 97% yet to be discovered!

You do not have access to this resource.
Click here to request your free trial access!

Already subscribed? Log in!


The Ultimate Scientific and Technical Reference

A Comprehensive Knowledge Base, with over 1,200 authors and 100 scientific advisors
+ More than 10,000 articles and 1,000 how-to sheets, over 800 new or updated articles every year
From design to prototyping, right through to industrialization, the reference for securing the development of your industrial projects

This article is included in

Drugs and pharmaceuticals

This offer includes:

Knowledge Base

Updated and enriched with articles validated by our scientific committees

Services

A set of exclusive tools to complement the resources

Practical Path

Operational and didactic, to guarantee the acquisition of transversal skills

Doc & Quiz

Interactive articles with quizzes, for constructive reading

Subscribe now!

Ongoing reading
MCR and functionalized isonitriles