Article | REF: PHA1512 V1

Functionnal enzymology-Viral and bacterial enzymes

Authors: Julien Dumond, Serge Kirkiacharian

Publication date: January 10, 2023

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1. Viral enzymes

Among viral enzymes, hydrolases (EC 3) and transferases (EC 2) occupy a prominent place. Some of these may have two or more catalytic activities, and are shown here by way of example. Proteases, glycosidases, helicases, integrases, NTPases, glycosyl-transferases, methyl-tranferases and phosphotransferases are presented in detail.

1.1 Hydrolases

Together with polymerases, viral proteases (EC 3) are essential catalysts for the development of many viruses. Indeed, the genomes of some viruses, once transcribed, take the form of polycistronic RNA+. A polycistronic RNA corresponds to a succession of cistrons encoding several protein chains. These RNAs are translated into polyproteins. A viral polyprotein contains several viral proteins that have not been separated....

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Viral enzymes