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7. Advantage of amorphous state for solubility and oral absorption
7.1 The problem of poorly soluble substances
When administered orally, an AP must be absorbed into the systemic circulation. This absorption involves two stages: dissolution in gastrointestinal (GI) fluids, followed by permeation through the GI membrane. Solubility and permeability form the basis of the biopharmaceutical classification system (BCS) (figure 18 a). For absorption to be effective, the active molecules in solution must be in...
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Advantage of amorphous state for solubility and oral absorption
Amorphous Solid Dispersions (ASD) of a PA in a polymer
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