Overview
FrançaisABSTRACT
For the last decade, Mesoporous Silica Nanoparticles (MSN) have been synthesized. These particles have a diameter of 60-300nm and possess a mesoporous hexagonally structured network with a 1.5 to 10nm pore diameter. They also have a specific surface area of approximately 1000 m2g-1. They show unique properties such as a large specific surface area and a narrow pore size distribution. They can be easily functionalized and are biocompatible, which makes them ideal candidates for biological applications. MSN have been used for the fluorescence labeling of biological materials, using one or two-photon dyes encapsulated in the pores of the nanoparticles. They are also used in gene transfection or as contrast agents in Magnetic Resonance Imaging (MRI). Finally, controlled drug-release systems are one of the most promising applications of MSN for the improvement of human health. New synthesis methods may even provide more functionalities to those particles.
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INTRODUCTION
Obtaining materials with perfectly controlled structuring and nanometric-sized objects can have applications in the fields of electronics, the environment, biology and medicine. In the 90s, Mobil Corporation Materials
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Mesoporous silica nanoparticles (MSN) and biological applications
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