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6. Conclusion
We have described lipid nanovectors used as nanomedicines, with particular reference to lipid nanoemulsions and their solid derivatives. The core of these systems is crucial to their role as carriers. In fact, the lipids that make up the core have a wide range of physical properties, from crystalline to liquid to amorphous solid. It is therefore essential to characterize these states, which can influence the stability and biological interaction of nanoparticles, as well as their encapsulation properties and the release kinetics of molecules of interest. Lipid nanoemulsions have already enjoyed industrial success in cosmetics and dermatology, thanks to less stringent regulations than those applied to pharmaceutical products. However, their potential in terms of industrialization and vectorization of lipophilic active molecules points to innovative applications in sectors such as vaccination...
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Conclusion
Bibliography
Digital media
CNRS sagascience: vectorization file http://www.cnrs.fr/cw/dossiers/dosnano/decouv/vecto/vecto.htm
Websites
NANOSAFE: use and production of nanomaterials http://www.nanosafe.org
Events
World Congress on Emulsion. International trade fair on fundamental and applied aspects of emulsions, held every 4 years at the Palais des Congrès in Lyon, France. http://www.cme-emulsion.com
PharmSciFair. International trade fair on fundamental and applied aspects of pharmaceutical sciences, held every 2 years in a European city....
Standards and norms
European Technological Platform for Nanomedecine, Nanotechnology for Health: Vision paper and basis for a strategic research agenda for nanomedecine, ETPN, 2005, European Commission Publication Office, Brussels
Cancer Nanotechnology Plan: a strategic initiative to transform clinical oncology and basic research through the direct application of nanotechnology, NIOH, National Cancer Institute,...
Regulations
Agence Nationale de Sécurité du Médicament et des Produits de Santé ANSM: an agency whose mission is to guarantee the safety of healthcare products throughout their life cycle. It issues marketing authorizations for drugs (AMM) and clinical trial authorizations. http://ansm.sante.fr
US Food and Drug Administration: federal agency regulating...
Patents
Recent advances and patents on Solid Lipid nanoparticles. in Recent patent on drug delivery and formulation, 2008, 2, 120-135
Process for producing nano-emulsions. WO/2008/104717
Encapsulation of lipophilic or amphiphilic therapeutic agents in nanoemulsions. WO/2010/018223
Lipid nanocapsules, preparation method and use as medicine. WO/2001/064328...
Directory
Manufacturers – Suppliers – Distributors (non-exhaustive list)
GEA Niro Soavi, suppliers of high-pressure homogenizers http://www.nirosoavi.com
Microfluidics Corporation, suppliers of microfluidic homogenizers http://www.microfluidicscorp.com
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