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Article | REF: PHA2032 V1

Amorphous and glassy states of molecular and pharmaceutical compounds Applications and uses

Author: Marc DESCAMPS

Publication date: April 10, 2020

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9. Co-amorphs

Amorphous polymer-based solid dispersions are widely used to stabilize amorphous materials and improve the oral bioavailability of poorly soluble PAs in the crystalline state . However, the use of polymer-based DSA has limitations. Many polymers are hygroscopic, which can lead to high water absorption. This plasticizes the system, thereby increasing the molecular mobility of PAs and facilitating their cris-tallization

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