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8. Other pKa determination methods
We now mention a few other methods of pK a determination, briefly outlining their principle.
8.1 Determination by solubility measurements
Let's take the HA/A pair – . Let's think in terms of concentrations. Assume that the HA acid form is only slightly soluble. Let S i be its solubility (mol · L –1 ) at a given temperature. S i is called the intrinsic solubility. Its total solubility S is given by the expression :
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Other pKa determination methods
Bibliography
Websites
pK a values compiled by R. WIlliams http://www.fm.ehcc.kyoto-u.ac.jp/pKa_compilation_Williams_RipinEvans.pdf
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